SC²S Colloquium - December 6, 2012

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Date: December 6, 2012
Room: 02.07.023
Time: 3:00 pm, s.t.

Adrian Alfredo Hernández Méndez: Simulating the interactions between T Cells and DCs in an heterogeneous field of cytokines

The cytokines play an important role in T cell activation. Indeed, it has been used for the creation of cancer therapies. This research project aims to study the role of gradient of cytokines in the interactions between Dendritic Cells (DCs) and T cells. Cellular Potts Model was used to model the interactions between cells and the diffusion equation governing the dynamics of cytokines.

Mihail Georgiev: Ewald-Based Methods for Coulombic Systems

Simulating the interactions of electrically charged particles is sometimes critical in creating accurate simulations. A leading class of methods for solving this problem is the Ewald summation, which breaks down the electrostatic attraction into two parts: a short-range, rapidly converging component that can be solved via a standard linked-cell algorithm, and a long-range, slowly converging component. This latter component can be solved in multiple ways, of which I will compare direct summation to the so-called smooth particle mesh method, which involves interpolating the particle potentials to a grid, which allows the use of a fast Poisson solver. Recent enhancements to the FFTW3 library allow for speed improvement in this area. I will also present the considerations taken in domain decomposition.

Validation of the results is another consideration. I will present some fairly generalized approaches with analytic solutions, the superposition of which allows for building fairly complex test geometries, including rings and lines of particles in arbitrary orientations.